Tissue-specific functions of p53 during kidney development
Results and Problems in Cell Differentiation, ISSN: 1861-0412, Vol: 60, Page: 111-136
2017
- 2Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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- Readers3
Book Chapter Description
p53 is best identified as a tumor suppressor for its transcriptional control of genes involved in cell cycle progression and apoptosis. Beyond its irrefutable involvement in restraining unchecked cell proliferation, research over the past several years has indicated a requirement for p53 function in sustaining normal development. Here I summarize the role of p53 in embryonic development, with a focus on knowledge gained from p53 loss and overexpression during kidney development. In contrast to its classical role in suppressing proliferative pathways, p53 positively regulates nephron progenitor cell (NPC) renewal. Emerging evidence suggests p53 may control cell fate decisions by preserving energy metabolism homeostasis of progenitors in the nephrogenic niche. Maintaining a critical level of p53 function appears to be a prerequisite for optimal nephron endowment. Defining the molecular networks targeted by p53 in the NPC may well provide new targets not only for regenerative medicine but also for cancer treatment.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85017515083&origin=inward; http://dx.doi.org/10.1007/978-3-319-51436-9_5; http://www.ncbi.nlm.nih.gov/pubmed/28409344; http://link.springer.com/10.1007/978-3-319-51436-9_5; https://dx.doi.org/10.1007/978-3-319-51436-9_5; https://link.springer.com/chapter/10.1007/978-3-319-51436-9_5
Springer Science and Business Media LLC
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