Drug release evaluation of mesoporous TiO: A nano carrier for duloxetine
Communications in Computer and Information Science, ISSN: 1865-0929, Vol: 341 CCIS, Page: 237-243
2012
- 4Citations
- 6Captures
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Conference Paper Description
Mesoporous TiO was synthesized solvothermally, but its XRD pattern proved little randomly arranged mesopores. Its DRS-UV-Vis spectrum showed characteristic band gap excitation just below 400 nm and oxygen to metal charge transfer close to 250 nm. It was loaded with the model drug duloxetine (DX) by wet method. Locked-in drug within the mesopores of TiO was confirmed by XRD, DRS-UV-Vis and FT-IR techniques. About 11% loading of drug was verified by UV-Vis spectroscopy. The study of drug release showed two stages of burst release between 0 and 12 h and beyond that slow extended release of DX occurred. The total burst release was equal to 20%, and even at the end of 40 h the total release was equal to 90%. Hence, mesoporous TiO was established as a viable, biocompatible DX reservoir for its controlled release. The same mesoporous TiO could be convenient for the release of potentially toxic drugs which require small and extended dose. © 2012 Springer-Verlag Berlin Heidelberg.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84869763272&origin=inward; http://dx.doi.org/10.1007/978-3-642-35248-5_33; http://link.springer.com/10.1007/978-3-642-35248-5_33; http://link.springer.com/content/pdf/10.1007/978-3-642-35248-5_33; https://dx.doi.org/10.1007/978-3-642-35248-5_33; https://link.springer.com/chapter/10.1007/978-3-642-35248-5_33
Springer Science and Business Media LLC
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