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Functional imaging of ovarian cancer and peritoneal carcinomatosis

Functional Imaging in Oncology: Clinical Applications - Volume 2, Page: 877-900
2014
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Book Chapter Description

Imaging plays an integral role in the diagnosis and management of ovarian cancer. The value of conventional anatomical modalities, such as ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI), in the detection, characterisation and staging of ovarian pathology is widely established in clinical practice. Current advances in imaging include the supplementation of pure morphological depiction at a macroscopic level with visualisation and quantification of functional properties of tissue, in an effort to provide noninvasive biomarkers of disease activity and its response to treatment. Modalities, such as diffusion-weighted imaging (DWI), dynamic contrast-enhanced MRI (DCE-MRI), proton magnetic resonance spectroscopy (1H-MRS), [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) and molecularly targeted PET radiotracers, radioimmunoscintigraphy (RIS) and near-infrared (NIR) optimal imaging, explore the microstructure, perfusion, biochemical composition and metabolism of ovarian tumours in vivo; their impact in diagnosis, surveillance and treatment planning and monitoring are mostly under investigation. This chapter reviews the functional imaging techniques employed in ovarian cancer and peritoneal carcinomatosis in the clinical and experimental setting and discusses their advantages, limitations and potential utility in improving management strategies.

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