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Modulation of X-ray-induced apoptosis in human keratinocytes (HaCaT) by 1,25-dihydroxyvitamin D3.

Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer, ISSN: 0080-0015, Vol: 164, Page: 427-432
2003
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Article Description

Possible effects of 1,25-dihydoxyvitamin D3 (vitamin D) on ionizing radiation-induced cell damage have been unknown until now. The task of the present study was to analyze, in a human keratinocyte cell line (HaCaT), the effects of a preincubation with vitamin D on the X-ray-induced mRNA expression of different genes related to apoptosis (gene array). The first results show that ionizing radiation leads to a down-regulation of various apoptosis-relevant genes in HaCaT cells pretreated with vitamin D. Therefore it can be speculated that vitamin D could prove to be a promising radioprotective substance.

Bibliographic Details

Meineke, Viktor; Pfaffendorf, Carolina; Schinn, Michaela; Tilgen, Wolfgang; Mayerhofer, Artur; Dimitrijevic, Nicola; van Beuningen, Dirk; Reichrath, Jörg

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

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