The HCMV gene products US2 and US11 target MHC class I molecules for degradation in the cytosol
Current Topics in Microbiology and Immunology, ISSN: 0070-217X, Vol: 269, Page: 37-55
2002
- 42Citations
- 26Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations42
- Citation Indexes42
- 42
- CrossRef7
- Captures26
- Readers26
- 26
Book Chapter Description
Over millions of years of coevolution with their hosts, viruses have developed highly effective strategies to elude the host immune system. The degradation of major histocompatibility complex (MHC) class 1 heavy chains by human cytomegalovirus (HCMV) is an example of this. Two HCMV proteins, US2 and US11, target newly synthesized MHC class 1 heavy chains for destruction via a pathway that involves ubiquitin-dependent retrograde transport, or "dislocation", of the heavy chains from the ER to the cytosol, where the proteins are degraded by proteasomes. In this review, US2- and US11-mediated degradation of MHC class 1 heavy chains is discussed in relation to data concerning the degradation of other ER luminal proteins. A new. unified model for translocon-facilitated dislocation and degradation of MHC class 1 heavy chains is presented. © Springer-Verlag Berlin Heidelberg 2002.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0035988010&origin=inward; http://dx.doi.org/10.1007/978-3-642-59421-2_3; http://www.ncbi.nlm.nih.gov/pubmed/12224515; http://link.springer.com/10.1007/978-3-642-59421-2_3; https://dx.doi.org/10.1007/978-3-642-59421-2_3; https://link.springer.com/chapter/10.1007/978-3-642-59421-2_3
Springer Science and Business Media LLC
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