Evaluation of cell line suitability for disease specific perturbation experiments
Studies in Classification, Data Analysis, and Knowledge Organization, ISSN: 1431-8814, Vol: 48, Page: 297-307
2015
- 1Citations
- 4Captures
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Conference Paper Description
Cell lines are widely used in translational biomedical research to study the genetic basis of diseases. A major approach for experimental disease modeling are genetic perturbation experiments that aim to trigger selected cellular disease states. In this type of experiments it is crucial to ensure that the targeted diseaserelated genes and pathways are intact in the used cell line. In this work we are developing a frameworkwhich integrates genetic sequence information and diseasespecific network analysis for evaluating disease-specific cell line suitability.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84945559938&origin=inward; http://dx.doi.org/10.1007/978-3-662-44983-7_26; https://link.springer.com/10.1007/978-3-662-44983-7_26; https://dx.doi.org/10.1007/978-3-662-44983-7_26; https://link.springer.com/chapter/10.1007/978-3-662-44983-7_26
Springer Science and Business Media LLC
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