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Regulation of dendritic cell development by STATs

Jak-Stat Signaling: From Basics to Disease, Page: 169-186
2012
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Book Chapter Description

Dendritic cells (DCs) serve as a critical link between the innate and adaptive immune responses due to their ability to sense pathogens and respond by activating adaptive immune cell types. Delineating the molecular control of DC development will provide important information about the generation of natural immunity as well as approaches to regulate DCs in clinical settings. DCs are generated from hematopoietic stem cells through specialized progenitor subsets in response to cytokine and transcriptional cues, with FMS-like tyrosine kinase 3 ligand (Flt3L) and Flt3L receptor (Flt3) signaling providing a major pathway supporting homeostatic DC generation. Recent work has indicated that granulocyte-macrophage colony-stimulating factor (GM-CSF) and type I interferons (IFNs) also play important roles in regulating DC subset production. Here we review new insight into the mechanisms by which cytokine-activated STAT proteins control the DC developmental process.

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