O-Glycans in Mammalian Notch Signaling
Glycoscience: Biology and Medicine, Page: 857-864
2015
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Book Chapter Description
Notch signaling occurs following the activation of membrane-bound Notch receptors by canonical Notch ligands expressed in neighboring cells. It is a fundamental requirement for the regulation of cell fate decisions during organellar differentiation in mammals. The extracellular domain of Notch receptors comprises numerous epidermal growth factor-like (EGF) repeats, many of which are modified by glycans O-linked to Ser or Thr at specific consensus sites. This chapter will summarize the nature and functions of O-Fucose, O-Glucose, O-GlcNAc, and O-GalNAc glycans in mammalian cells, mouse development, and human disease. Congenital diseases that arise from reduced addition of O-glycans reveal the importance of these modifications for Notch signaling.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84943601124&origin=inward; http://dx.doi.org/10.1007/978-4-431-54841-6_165; https://link.springer.com/10.1007/978-4-431-54841-6_165; https://dx.doi.org/10.1007/978-4-431-54841-6_165; https://link.springer.com/referenceworkentry/10.1007/978-4-431-54841-6_165
Springer Science and Business Media LLC
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