MicroRNAs in hepatocellular carcinoma
MicroRNAs in Cancer Translational Research, Page: 163-188
2011
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
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Book Chapter Description
Hepatocellular carcinoma (HCC) is a major type of liver cancer. It is the third leading cause of cancer-related death worldwide. MicroRNAs (miRNAs), a class of small non-coding RNAs, are aberrantly expressed in HCC. The genomic instability, transcriptionally regulation, and epigenetic alteration have been identified to contribute to the abnormal expression of miRNAs in HCC. Moreover, deregulation of miRNAs not only functionally enables liver tumorigenesis, but also promotes tumor progression. Further, aberrant expression of certain miRNAs is correlated with clinical features of HCC, indicating their potential to serve as diagnostic and prognostic biomarkers of HCC. Several miRNAs have been validated in independent cohorts as HCC biomarkers, paving the way for developing clinically useful platforms to aid in diagnosis and prognosis for patients, and to assist in HCC patient stratification with the potential for personalized adjuvant therapy. In addition, several oncogenic and tumor suppressive miRNAs are being exploited as possible therapeutic targets in HCC. In this chapter, recent studies on miRNA and HCC, particularly those that are clinically relevant, are discussed. © 2011 Springer Science+Business Media B.V.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84900225933&origin=inward; http://dx.doi.org/10.1007/978-94-007-0298-1_7; https://link.springer.com/10.1007/978-94-007-0298-1_7; https://dx.doi.org/10.1007/978-94-007-0298-1_7; https://link.springer.com/chapter/10.1007/978-94-007-0298-1_7; http://www.springerlink.com/index/10.1007/978-94-007-0298-1_7; http://www.springerlink.com/index/pdf/10.1007/978-94-007-0298-1_7
Springer Science and Business Media LLC
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