Vanadium in cancer prevention
Vanadium: Biochemical and Molecular Biological Approaches, Vol: 9789400709133, Page: 163-185
2012
- 15Citations
- 9Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Book Chapter Description
The pharmacological role of vanadium in health and disease remains one of the fascinating stories in biology. Recent studies have established vanadium as a novel regulator in assessing physiological and biochemical states of the animals. Vanadium exhibits biphasic effect, essentiality at low concentrations (0.05 μM) and toxicity at high doses (>10 μM). Vanadium inhibits growth of transformed cancer cells in culture. Various laboratories have confirmed the antitumorigenic potential of vanadium in liver, breast and colon cancer in vivo and various human cancer epithelial cell lines in vitro. Antiproliferative and induction of apoptosis may be the major mechanism of vanadium mediated inhibitions of cancer. Vanadium can play a central role in modulating phosphorylation states of various proteins in the cell and can affect many cellular processes regulated by cyclic AMP. In human vanadium is of interest pharmacologically but confirmation to its essentiality will require more significant information from experimental, clinical and epidemiological studies.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84930918119&origin=inward; http://dx.doi.org/10.1007/978-94-007-0913-3_8; https://link.springer.com/10.1007/978-94-007-0913-3_8; http://www.springerlink.com/index/10.1007/978-94-007-0913-3_8; http://www.springerlink.com/index/pdf/10.1007/978-94-007-0913-3_8; https://dx.doi.org/10.1007/978-94-007-0913-3_8; https://link.springer.com/chapter/10.1007/978-94-007-0913-3_8
Springer Science and Business Media LLC
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