Role of microenvironment in regulating stem cell and tumor initiating cancer cell behavior and its potential therapeutic implications
Tumor Dormancy, Quiescence, and Senescence, Volume 2: Aging, Cancer, and Noncancer Pathologies, Page: 301-312
2014
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Book Chapter Description
Microenvironment plays a key role in controlling stem cell fate and thereby regulating tissue homeostasis and repair. It consists of acellular and cellular components that interact with stem cells and their progenitors and through signaling cascades infl uence balance between self-renewal, differentiation and dormancy. Under pathological conditions, disruptions in microenvironment can generate signals that stimulate untimely or aberrant stem cell differentiation or self-renewal, or activate de-differentiation of progenitor cells, leading to diseased states such as cancer. However, while unaltered microenvironment can restrain transformed cell behavior inhibiting malignant phenotypes, transformed cancer cells that exhibit resistance to conventional therapies and tumor initiating capacity are capable of inducing more permissive and immunotolerant microenvironment that promotes tumor growth and metastasis. Better understanding of their behavior and interactions with microenvironment opens up novel avenues for devising more effi cacious cancer therapies.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84906874626&origin=inward; http://dx.doi.org/10.1007/978-94-007-7726-2_28; https://link.springer.com/10.1007/978-94-007-7726-2_28; https://dx.doi.org/10.1007/978-94-007-7726-2_28; https://link.springer.com/chapter/10.1007/978-94-007-7726-2_28
Springer Science and Business Media LLC
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