Role of tissue factor-FVIIa blood coagulation initiation complex in cancer

Since a century ago, an intricate relationship exists between cancer progression and thromboembolism. In various case studies, thromboembolic complications have been found to maintain an intricate relationship with the progression of various tumours like breast, lung, colon and glioblastoma. Moreover, coagulation factors have also been reported to be involved for metastatic augmentation complications in cancer patients with elevated levels of complication in cancer- associated thrombosis. Production and protease activity of various coagulation factors like thrombin and tissue factor (TF)-FVIIa complex affect tumour progression and propagation actively. TF exerts both coagulant as well as PAR2- dependent cancerous activity by eliciting various cell survival signalling pathways, like P42/44MAPK and PI3K/AKT. However, the molecular elucidation of the role of these coagulation factors in cancer-associated thrombosis and metastatic progression has not been understood till date.