Impact of Osmolytes in Conformational Modulation of Protein and Its Applications in Biotechnology
Cellular Osmolytes: From Chaperoning Protein Folding to Clinical Perspectives, Page: 143-160
2017
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- 9Captures
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Book Chapter Description
Cells utilize small molecules osmolytes to defend themselves from the stressed environmental conditions. These osmolytes protect the cells by stabilizing the protein against misfolded or aggregated conformation. This is important because aggregation, misfolding and destabilization of the protein lead to several life-threatening neurodegenerative disorders. So, we have thrown light on some of the properties of the osmolyte which assist in protein folding, increases their stability and inhibit aggregation. Osmolytes are also known as chemical chaperones. Hence, it may be therapeutically used for several misfolding diseases. The present chapter discusses the impact of these small molecules on folding of proteins and their stabilization.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85033359232&origin=inward; http://dx.doi.org/10.1007/978-981-10-3707-8_7; http://link.springer.com/10.1007/978-981-10-3707-8_7; https://dx.doi.org/10.1007/978-981-10-3707-8_7; https://link.springer.com/chapter/10.1007/978-981-10-3707-8_7
Springer Science and Business Media LLC
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