Cancer Stem Cells in Therapy Resistance of Colorectal Cancer
Handbook of Oxidative Stress in Cancer: Therapeutic Aspects: Volume 1, Vol: 1, Page: 2101-2116
2022
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Book Chapter Description
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide, and therapy resistance is one of the most common reasons for treatment failure in CRC. Cancer stem cells (CSCs) are a minor subpopulation of tumor cells with the capacity of self-renewal and differentiation, which play an important role in the progression, recurrence, and therapy resistance of cancer. Recent studies have shown that CSCs induce cancer resistance to conventional treatments through a variety of mechanisms, including targeting signaling pathways, regulating level of microRNAs, DNA damage repair, maintaining low levels of reactive oxygen species (ROS), and maintaining a relatively quiescent state. Therefore, therapeutic strategies targeting CSCs may be able to reverse therapy resistance of CRC, but the lack of specific CSC markers also confuses this therapeutic strategy. In this chapter, we will discuss the effect of CSCs on CRC therapy resistance and its potential mechanism, the current research progress of the strategy of targeting CSCs, and their existing problems in order to provide a reference for the selection of therapeutic strategies for CRC.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85160468101&origin=inward; http://dx.doi.org/10.1007/978-981-16-5422-0_102; https://link.springer.com/10.1007/978-981-16-5422-0_102; https://dx.doi.org/10.1007/978-981-16-5422-0_102; https://link.springer.com/referenceworkentry/10.1007/978-981-16-5422-0_102
Springer Science and Business Media LLC
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