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A General Overview on Causes, Risk Factors, Diagnosis, Treatment, and Role of Oxidative Stress Biomarkers in Colorectal Cancer

Handbook of Oxidative Stress in Cancer: Therapeutic Aspects: Volume 1, Vol: 1, Page: 3877-3895
2022
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Book Chapter Description

Colorectal cancer is the third most common cancer that exhibited low incidence several years ago. Now it is becoming a prime cancer that is accountable for about 10% of cancer-related deaths in Western parts. In developed countries, colorectal cancer is emerging due to the population with increased age, unhealthy dietary habits, and higher risk factors including smoking, alcohol consumption, and lack of physical activities. Advanced therapies to treat primary and metastatic diseases include various options ranging from laparoscopic surgery, neoadjuvant chemotherapy, radiotherapy for rectal tumor, and targeted therapies. Nevertheless, these therapies have restricted effects on curative and overall survival rates. Thus, screening programs are now gaining increased attention in this disease prevention. In this review, we present an overview of etiology, causes and molecular pathophysiology, current diagnosis, and therapies as well as information on the role of oxidative stress biomarkers in colorectal cancer.

Bibliographic Details

Sushmitha Sriramulu; Sarubala Malayaperumal; Dikshita Deka; Antara Banerjee; Surajit Pathak

Springer Science and Business Media LLC

Medicine; Biochemistry, Genetics and Molecular Biology

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