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Mining for Biosynthetic Gene Clusters in Actinobacteria Genomes Via Bioinformatics Tools

Actinobacteria: Microbiology to Synthetic Biology, Page: 121-134
2022
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Book Chapter Description

Genome mining using next-generation sequencing (NGS) technologies and bioinformatics tools opens the way to understand secondary metabolite biosynthesis potentials of Actinobacteria. Reads of different lengths are produced using technologies like Illumina, Ion Torrent, PacBio, and ONT. These reads are used to reconstruct the original genome using Metagenomic assembly approaches. Genome annotation then detects the coding loci and identifies their protein products. Many in silico genome mining softwares allow the identification of secondary metabolites biosynthetic gene clusters (smBGCs) as well as detection of unique genes. These novel technologies will allow the production of new bioactive compounds.

Bibliographic Details

Omnia Mohamed Abdallah; Alaa Fayez Elsayed; Amal Mohamed Shawky; Dina Hatem Amin

Springer Science and Business Media LLC

Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences

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