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Crohn’s Disease-Associated Lower Gastrointestinal Cancer

Atlas of Inflammatory Bowel Disease-Associated Intestinal Cancer: Examining the Macroscopic Images of Small and Large Intestine, Page: 11-17
2022
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Book Chapter Description

Crohn’s disease (CD) carries the same risk of carcinogenesis as ulcerative colitis (UC) [1], and the number of CD-associated cancer cases is increasing in Japan concurrent with an increase in the number of long-term cases [2]. However, the number of CD cases complicated with cancer is much lower than that of UC cases complicated with cancer. Additionally, the morphological analysis of CD-associated gastrointestinal cancers is not as advanced because the entire gastrointestinal tract is at risk; endoscopy is limited by stenosis, fistulae, and anal lesions; and frequency of CD-associated cancers is high in the rectal and anal regions, where gastroenterologists are least familiar. In this chapter, we present our experience with CD-associated lower gastrointestinal cancers and describe current issues, focusing on diagnosis [3]. The description of the presented cases is included in Sect. 3 of the text, and the corresponding cases are indicated by (). The description of cancer lesions is based on the 9th edition of the Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma [4].

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