Gastric cancer: Epigenetic mechanisms: Aberrant DNA methylation and dysregulation of microRNA
Helicobacter pylori, Page: 257-267
2016
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Book Chapter Description
Like many human cancers, global DNA hypomethylation and promoter CpG island hypermethylation in tumor suppressor or tumor-related genes are frequently observed in gastric cancer, and aberrant DNA methylation occurs in a gene-specific manner during the multistep gastric carcinogenesis. Chronic Helicobacter pylori (H. pylori) infection induces proinflammatory cytokines and reactive oxygen and nitrogen species in the gastric mucosa, which is known to be associated with the accumulation of aberrant DNA methylation. Aberrant DNA methylation caused by H. pylori-associated gastritis persists even after the disappearance of H. pylori, and epigenetic alterations induced by H. pylori correlate with the risk for gastric cancer. Numerous microRNAs (miRNAs) are dysregulated during the gastric carcinogenesis, and some of these miRNAs are known to be also dysregulated by H. pylori infection. miRNAs dysregulated by H. pylori infection play an important role in gastric carcinogenesis by modulating inflammation and immune response of the host, cell cycle progression, apoptosis and proliferation, and tumor invasion and metastasis.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85030261579&origin=inward; http://dx.doi.org/10.1007/978-981-287-706-2_23; http://link.springer.com/10.1007/978-981-287-706-2_23; https://doi.org/10.1007%2F978-981-287-706-2_23; https://dx.doi.org/10.1007/978-981-287-706-2_23; https://link.springer.com/chapter/10.1007/978-981-287-706-2_23
Springer Science and Business Media LLC
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