Mycobacterium tuberculosis heat shock protein 10 increases both proliferation and death in mouse P19 teratocarcinoma cells
In Vitro Cellular and Developmental Biology - Animal, ISSN: 1071-2690, Vol: 32, Issue: 7, Page: 446-450
1996
- 13Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations13
- Citation Indexes13
- 13
- CrossRef11
- Captures7
- Readers7
Article Description
Exogenously added Mycobacterium tuberculosis Hsp10, either synthetic or recombinant, but not other related heat shock proteins (GroES from Escherichia coli or bovine Ubiquitin), increases apoptosis in serum-deprived P19 mouse teratocarcinoma cells. The effect is dose-dependent, with a bell- shaped curve and peak activity at 10 M (maximal effect: 62.9 ± 17.7% increase, mean ± SD, n = 10) and is specifically inhibited by a polyclonal antibody raised against the synthetic protein. On the other hand, when the same cells are exponentially growing, M. tuberculosis Hsp10 increases cell proliferation with a bell-shaped dose-response curve and a moderate decrease in potency (peak-activity at 10-10 M, with a 43.7 ± 8.1% increase, mean ± SD, n = 3). Therefore, it appears that this bacterial protein can exert two opposite effects, behaving either as a death- or as a growth- promoting factor, depending on the conditions of the target.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0029745707&origin=inward; http://dx.doi.org/10.1007/bf02723008; http://www.ncbi.nlm.nih.gov/pubmed/8856346; http://link.springer.com/10.1007/BF02723008; http://www.springerlink.com/index/pdf/10.1007/BF02723008; http://www.springerlink.com/index/10.1007/BF02723008; https://dx.doi.org/10.1007/bf02723008; https://link.springer.com/article/10.1007/BF02723008
Springer Nature
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