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Mycobacterium tuberculosis heat shock protein 10 increases both proliferation and death in mouse P19 teratocarcinoma cells

In Vitro Cellular and Developmental Biology - Animal, ISSN: 1071-2690, Vol: 32, Issue: 7, Page: 446-450
1996
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Exogenously added Mycobacterium tuberculosis Hsp10, either synthetic or recombinant, but not other related heat shock proteins (GroES from Escherichia coli or bovine Ubiquitin), increases apoptosis in serum-deprived P19 mouse teratocarcinoma cells. The effect is dose-dependent, with a bell- shaped curve and peak activity at 10 M (maximal effect: 62.9 ± 17.7% increase, mean ± SD, n = 10) and is specifically inhibited by a polyclonal antibody raised against the synthetic protein. On the other hand, when the same cells are exponentially growing, M. tuberculosis Hsp10 increases cell proliferation with a bell-shaped dose-response curve and a moderate decrease in potency (peak-activity at 10-10 M, with a 43.7 ± 8.1% increase, mean ± SD, n = 3). Therefore, it appears that this bacterial protein can exert two opposite effects, behaving either as a death- or as a growth- promoting factor, depending on the conditions of the target.

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