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A computational study of the effects of serotonin on a molluscan burster neuron

Biological Cybernetics, ISSN: 0340-1200, Vol: 69, Issue: 3, Page: 257-267
1993
  • 31
    Citations
  • 0
    Usage
  • 4
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    31
    • Citation Indexes
      31
  • Captures
    4

Article Description

A mathematical model of burster neuron R from the abdominal ganglion of Aplysia is presented. This is an improvement over earlier models in that the bursting mechanism is more accurately represented. The improved model allows for simulated application of the neurotransmitter serotonin, which has been reported to have profound effects on the voltage waveform produced by R. Computational analysis indicates that the serotonin-induced modulation of the waveform can be explained in terms of competition between stationary, bursting, and beating attractors. Analysis also indicates that, as a result of this competition, serotonin increases the sensitivity of the neuron to synaptic perturbations. This may have important consequences with regard to water balance in the Aplysia, particularly during egg laying. © 1993 Springer-Verlag.

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