Comparative and combined effects of transforming growth factors α and β, interleukin-1 and interferon-γ on rheumatoid synovial cell proliferation, glycolysis and prostaglandin E production
Rheumatology International, ISSN: 0172-8172, Vol: 9, Issue: 2, Page: 65-70
1989
- 11Citations
- 3Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations11
- Citation Indexes11
- 11
- CrossRef7
- Captures3
- Readers3
Article Description
Enhanced cell proliferation, glycolysis and prostaglandin E production are all characteristic features of rheumatoid synovial tissue. The interrelationships of these three cellular parameters have been examined using rheumatoid synovial fibroblasts and their responses to specific cytokines in vitro. Transforming growth factor α (TGFα) caused a more than threefold increase in synovial cell proliferation whilst transforming growth factor β (TGFβ), interleukin-1α (IL-1α) and interferon-γ (IFN-γ) produced only marginal changes. The combined addition of IL-1α with TGFβ resulted in an enhanced proliferative response comparable with that produced by TGFα. Glycolysis, estimated by glucose utilisation and measurements of the glycolytic regulatory metabolite fructose 2,6-bisphosphate was significantly stimulated by TGFβ, IL-1α and IFN-γ, but less so by TGFα. Prostaglandin E production was significantly increased by IL-1α to an extent much greater than that produced by TGFα or TGFβ, although the combined addition of IL-1α with either TGFα or β resulted in a synergistic increase in PGE production, a response partly diminished by the addition of IFN-γ. These findings suggest that the extent to which a cytokine stimulates glycolysis is not consistently related to its mitogenicity, and that cytokine combinations which stimulate high levels of PGE production (a growth inhibitor) will not necessarily be associated with a reduced rate of cellular proliferation in cultured, adherent, rheumatoid synovial fibroblasts. © 1989 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024421699&origin=inward; http://dx.doi.org/10.1007/bf00270247; http://www.ncbi.nlm.nih.gov/pubmed/2510238; http://link.springer.com/10.1007/BF00270247; http://www.springerlink.com/index/10.1007/BF00270247; http://www.springerlink.com/index/pdf/10.1007/BF00270247; https://dx.doi.org/10.1007/bf00270247; https://link.springer.com/article/10.1007/BF00270247
Springer Science and Business Media LLC
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know