Blood flow patterns in painful diabetic neuropathy
Diabetologia, ISSN: 0012-186X, Vol: 27, Issue: 6, Page: 563-567
1984
- 147Citations
- 27Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations147
- Citation Indexes146
- 146
- CrossRef99
- Policy Citations1
- Policy Citation1
- Captures27
- Readers27
- 27
Article Description
Peripheral blood flow is known to be qualitatively increased in diabetic patients with neuropathy. We have measured the actual blood flow in the feet of diabetic patients with neuropathy using non-invasive mercury strain gauge plethysmography and Doppler sonogram techniques and shown that it is increased on average five times above normal at an ambient temperature of 20 °-22 °C. Moreover, reduction of this high flow by sympathetic arousal stimuli proved possible in those with severe painful neuropathy contrasting strongly with failure to reverse it in those with severe non-painful sensory neuropathy. Reduction of blood flow was associated with reduction in neuropathic pain. We studied 22 diabetic patients with severe sensory neuropathy and eight with painful neuropathy. High resting foot blood flows were demonstrated in both groups with neuropathy. The big toe flow in those with severe sensory neuropathy was 29.3±9.2 ml · min · 100 ml (mean±SD) and in the painful neuropathy group, 25.9±7.5, compared with 5.2±2.4ml · min · 100ml in the non-diabetic control subjects (p<0.001). High foot skin temperatures were also recorded in the groups with neuropathy, reflecting the high blood flow. The subjects with painful neuropathy retained the ability to constrict peripheral blood vessels in response to arousal stimuli, and reduce peripheral flow on average by 32% compared with the patients with sensory neuropathy who responded on average by only 10%. The demonstration of a peripheral sympathetic defect, responsible for the high blood flow and the potential reversal of such flow in painful neuropathy may be important in our further understanding of the aetiology of such pain and its treatment. © 1984 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0021715825&origin=inward; http://dx.doi.org/10.1007/bf00276968; http://www.ncbi.nlm.nih.gov/pubmed/6530051; http://link.springer.com/10.1007/BF00276968; http://www.springerlink.com/index/10.1007/BF00276968; http://www.springerlink.com/index/pdf/10.1007/BF00276968; https://dx.doi.org/10.1007/bf00276968; https://link.springer.com/article/10.1007/BF00276968
Springer Nature
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