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The proof of dimethylparatoluidine in bone cement even after long-time implantation

Archives of Toxicology, ISSN: 0340-5761, Vol: 51, Issue: 2, Page: 157-166
1982
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Metrics Details

  • Citations
    24
    • Citation Indexes
      24
  • Captures
    1

Article Description

Twenty-three specimen of methylmethacrylate-bone cement (PMMA), 30 days up to 101/4 years after their autopolymerization, has been analyzed in regard to the content of low-molecular substances. We were specially interested in the concentration of monomeres after long-time implantation, because the remainders of toxic monomeres are accused of being to be responsible for pathologic changes in bone site. The analysis was made gaschromatographically, the identification of the different substances was done by comparing them with the mass-spectra of pure substances. In none of the specimen could monomeres be detected. In 18 PMMA-specimen, implanted in man between 21/2 and 101/4 years 0.41 (±0.22)% w/w dimethyl-paratoluidine (DMpT) was found, as only detectible low-molecular substance. In 3 in vitro specimen the content of DMpT was 0.31 (±0.04)% w/w 30 days after polymerization. As an additional proof for the method used, no DMpT could be found in 2 specimen PMMA initiated with an different system, namely tri-n-butylborane, 30 days after polymerization. The relatively high concentration of DMpT in bone cement becomes understandable concerning the mechanism of the starting reaction. DMpT is well known to be toxic even in low concentration. © 1982 Springer-Verlag GmbH & Co KG.

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