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Effects of metopirone on the structure of endocrine glands in the male lizard, Cnemidophorus l. lemniscatus (L.)

Zeitschrift für Zellforschung und mikroskopische Anatomie, ISSN: 0302-766X, Vol: 135, Issue: 1, Page: 27-43
1972
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Adrenals, pituitary glands, thyroids, testes and kidneys of metopirone-treated and control male lizards were studied by light microscopy. Pituitary-interrenal axis: A great hypertrophy and hyperplasia of the interrenal cells and the pituitary corticotrophs were found in the experimental group. Pituitary-thyroid axis: Metopirone-treated animals showed a moderate hypertrophy and degranulation of pituitary thyrotrophs, and signs of uneven hyperactivity of the thyroid. Pituitary-testicular axis: By effect of metopirone, a marked regression of pituitary interstitiotrophs and a virtual disappearance of the testicular interstitial gland took place. The second portion of the kidney sexual segments appeared degranulated as in castrated animals. The pituitary folliculotrophs and the seminiferous epithelium of the testis did not show alterations. © 1972 Springer-Verlag.

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