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Estrogen receptors in mammary gland primordia of fetal mouse

Anatomy and Embryology, ISSN: 0340-2061, Vol: 158, Issue: 2, Page: 161-166
1980
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Swiss albino mice were injected on day 16 of pregnancy with H diethylstilbestrol. Fetuses were sacrificed 3h afterwards, frozen, and processed for thaw-mount autoradiography. The serial sections from 4 fetuses were studied. Intense nuclear concentration of radioactivity was found in the mesenchymal cells directly surrounding the epithelial primordia of the mammary glands, but not in the epithelium itself. Localization was similar in male and female fetuses. These findings are discussed in relation to their developmental, teratological, and oncological implications. © 1980 Springer-Verlag.

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