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The phagocytotic activity of permanent fibrocytes (strain l 929) under the effect of glucocorticoides (prednisolon) in dependence of concentration and time after application

Zeitschrift für Zellforschung und Mikroskopische Anatomie, ISSN: 0302-766X, Vol: 105, Issue: 1, Page: 123-136
1970
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  • Citations
    2
    • Citation Indexes
      2

Article Description

Glucocorticoides added to the nutritive fluid of permanent L-cell cultures in small, clinically used doses (2×10-2×10%) cause alterations of the phagocytosis activity of fibroblasts dependent on concentration. Low prednisolon concentrations increase, higher concentrations inhibit the phagocytotic activity of L-cells. The bimodal activity alteration is to be observed during the building-up of hormone concentration within the cells as well as during its decomposition. Maximal phagocytosis activation has been measured 1/2 to 1 hour after the hormone application on the L-cell strain (929) examined. This activation has only be partially influenced by the metabolism depressions characteristic of the glucocorticoid action. © 1970 Springer-Verlag.

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