Five-year follow-up of islet cell antibodies in Type 2 (non-insulin-dependent) diabetes mellitus
Diabetologia, ISSN: 0012-186X, Vol: 34, Issue: 6, Page: 402-408
1991
- 42Citations
- 6Captures
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Metrics Details
- Citations42
- Citation Indexes41
- 41
- CrossRef23
- Policy Citations1
- Policy Citation1
- Captures6
- Readers6
Article Description
The aim was to study the frequency and appearance of cytoplasmic islet cell antibodies in relation to impairment of insulin secretory capacity and some clinical characteristics in a representative group of middle-aged (45-64 years) patients with Type 2 (non-insulin-dependent) diabetes mellitus (70 male, 63 female) at the time of diagnosis and at five-year follow-up. Non-diabetic control subjects (62 male, 82 female) were similarly examined at five-year intervals. At the baseline five out of 133 (3.8%) diabetic patients were positive for conventional and four (3.0%) for complement-fixing islet cell antibodies. Ten patients had become positive by the second screening for conventional antibodies and six for complement-fixing antibodies, but none showed negative conversion. Two non-diabetic subjects (1.5%) became antibody positive during the follow-up. Insulin treatment was started during the follow-up for four out of 15 (27%) conventional antibody positive and for one out of 121 (0.8%) antibody negative diabetic patients (p=0.001). The sensitivity of the positive conventional and complement-fixing antibody for identifying patients who developed an impairment of insulin secretory capacity (post-glucagon C-peptide ≦0.60nmol/l at 5-year) was 75%. The respective specificity was 90% and the positive predictive values were highest in the case of high positivity (50%). The negative predictive value of antibody positivity was close to 100%. In conclusion, islet cell antibody positivity in patients classified as Type 2 was persistent during the follow-up and predicted the future development of insulin deficiency especially in those patients with high or increasing antibody titres. © 1991 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0025859332&origin=inward; http://dx.doi.org/10.1007/bf00403178; http://www.ncbi.nlm.nih.gov/pubmed/1884898; http://link.springer.com/10.1007/BF00403178; https://dx.doi.org/10.1007/bf00403178; https://link.springer.com/article/10.1007/BF00403178; http://www.springerlink.com/index/10.1007/BF00403178; http://www.springerlink.com/index/pdf/10.1007/BF00403178
Springer Nature
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