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Effect of chloroquine on proteolytic processes and energy metabolism in yeast

Archives of Microbiology, ISSN: 0302-8933, Vol: 137, Issue: 2, Page: 104-108
1984
  • 22
    Citations
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  • 6
    Captures
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Metrics Details

  • Citations
    22
    • Citation Indexes
      22
  • Captures
    6

Article Description

In yeast cells, degradation of cellular proteins was inhibited by addition of chloroquine to the medium as shown by a decrease of the release of trichloroacetic acid-soluble radioactivity from prelabelled cell protein. Penetration of chloroquine into the cells was strongly enhanced with increasing pH value of the medium. The concentration in the cells reached 5-14 times that in the medium of pH 8.0. Fluorescence microscopy showed that chloroquine was concentrated in the vacuoles of the cells. Chloroquine, at concentrations attained in the cells, inhibited the activities of vacuolar proteinases in vitro. Furthermore, chloroquine caused a rapid and drastic decrease of the ATP content of the cells and prevented the fermentation of glucose and formation of ethanol under aerobic conditions. © 1984 Springer-Verlag.

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