Effect of chloroquine on proteolytic processes and energy metabolism in yeast
Archives of Microbiology, ISSN: 0302-8933, Vol: 137, Issue: 2, Page: 104-108
1984
- 22Citations
- 6Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
In yeast cells, degradation of cellular proteins was inhibited by addition of chloroquine to the medium as shown by a decrease of the release of trichloroacetic acid-soluble radioactivity from prelabelled cell protein. Penetration of chloroquine into the cells was strongly enhanced with increasing pH value of the medium. The concentration in the cells reached 5-14 times that in the medium of pH 8.0. Fluorescence microscopy showed that chloroquine was concentrated in the vacuoles of the cells. Chloroquine, at concentrations attained in the cells, inhibited the activities of vacuolar proteinases in vitro. Furthermore, chloroquine caused a rapid and drastic decrease of the ATP content of the cells and prevented the fermentation of glucose and formation of ethanol under aerobic conditions. © 1984 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0021333526&origin=inward; http://dx.doi.org/10.1007/bf00414448; http://link.springer.com/10.1007/BF00414448; http://www.springerlink.com/index/pdf/10.1007/BF00414448; http://link.springer.com/content/pdf/10.1007/BF00414448; http://link.springer.com/content/pdf/10.1007/BF00414448.pdf; http://link.springer.com/article/10.1007/BF00414448/fulltext.html; https://dx.doi.org/10.1007/bf00414448; https://link.springer.com/article/10.1007/BF00414448; http://www.springerlink.com/index/10.1007/BF00414448
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