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Haematological response of dogs to canine recombinant granulocyte colony stimulating factor (rcG-CSF)

Comparative Haematology International, ISSN: 0938-7714, Vol: 2, Issue: 3, Page: 151-156
1992
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Article Description

Three beagle dogs were given 5 μg canine recombinant granulocyte colony stimulating factor (rcG-CSF)/kg/day for 42 days. One day after the first dose the neutrophil count exceeded the pretreatment counts by 3- to 4-fold. A steady and rapid increase occurred during days 1 to 12. In two of the dogs the counts continued to increase, but at a slower rate, from day 14 to 28. The neutrophil count in the third dog decreased steadily from day 14 to 28, although the count remained above those of the presample period and exceeded the reference range for dogs established at the Veterinary Medical Teaching Hospital, University of California, Davis. After day 28 that dog had a rapid increase in neutrophil count that reached similar numbers to the other two dogs at 34 days. At no time was a significant left shift found, although an occasional band neutrophil was observed. In addition, a moderate increase in lymphocyte and monocyte counts were found. The degree of these increases was much less than that of the neutrophils. The leukocyte counts decreased rapidly after the last dose, and 10 days later the counts were similar to those of the pretrial period. Concomitant with the marked neutrophilia, bone marrows showed myeloid hyperplasia. The myeloid: erythroid ratios increased from 1.03-1.65 to 2.77-7.03, and the marrow cellularity increased from approximately 30%-50% to about 85%-100%. Clinical evaluation and serum chemistry panels revealed no adverse affects. We conclude that rcG-CSF effectively sustains an increased neutrophil count without producing significant adverse effects. © 1992 Springer-Verlag.

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