Sequential appearance of fibronectin and collagen fibres in experimental arthritis in rabbits
Histochemistry, ISSN: 0301-5564, Vol: 80, Issue: 1, Page: 39-44
1984
- 9Citations
- 7Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations9
- Citation Indexes9
- CrossRef6
- Captures7
- Readers7
Article Description
The sequential changes in the presence of fibronectin in the synovial membrane during the development of antigen-induced arthritis in rabbits were studied using an indirect immunoperoxidase technique on the tissue specimens fixed in formaldehyde, embedded in paraffin and pretreated with pepsin and testicular hyaluronidase. The relation to the distribution of fibronectin and connective tissue fibres, demonstrated as either argyrophilic or red by van Gieson method, was studied. Initial after the induction of the arthritis the synoviocytes became increased in size and number. The subsynoviocytial tissue was invaded by granulocytes and the number of vessels was increased. Fibronectin in increased amount was seen around the lining cells. After 2-4 weeks a markedly reduced amount of granulocytes were seen together with an increase in the number of macrophages. At this stage, fibronectin was also found together with argyrophilic fibres in the subsynoviocytial connective tissue. After 8-13 weeks the synovial membrane was found hypertrophic and folded. The lining layer was unchanged, but in the subsynoviocytial tissue lymphocytes and plasma cells were more focally arranged. At that time fine fibres, stained by the van Gieson method, were present together with fibronectin and argyrophilic fibres in the subsynoviocytial tissue. The morphological change and the distribution of fibronectin in experimentally induced arthritis correlates temporally to the morphological change and the presence of fibronectin found in experimentally induced granulation tissue. © 1984 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0021337188&origin=inward; http://dx.doi.org/10.1007/bf00492769; http://www.ncbi.nlm.nih.gov/pubmed/6365852; http://link.springer.com/10.1007/BF00492769; http://www.springerlink.com/index/pdf/10.1007/BF00492769; http://www.springerlink.com/index/10.1007/BF00492769; https://dx.doi.org/10.1007/bf00492769; https://link.springer.com/article/10.1007/BF00492769
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