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On the mechanism of 1.8-dihydroxy-9-anthrone (anthraline) - The effect of 1.8-dihydroxy-9-anthrone on the RNA polymerase of rat liver nuclei in vitro

Archiv fur klinische und experimentelle Dermatologie, ISSN: 0300-8614, Vol: 235, Issue: 4, Page: 400-409
1969
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  • Citations
    9
    • Citation Indexes
      9

Article Description

1. After incubation with 1.8-dihydroxy-9-anthrone isolated rat liver nuclei show an increased RNA polymerase activity when compared to controls. 2. High concentrations of 1.8-dihydroxy-9-anthrone lead to an inhibitory effect. 3. The time-dependence of the in vitro-1.8-dihydroxy-9-anthrone effect on the activity of the RNA polymerase in liver nuclei and its specifity were investigated. 4. The effect of 1.8-dihydroxy-9-anthrone is actinomycin D sensitive. © 1969 Springer-Verlag.

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