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Die Genomsonderung während der durch Buttergelb induzierten Cancerogenese der Rattenleber

Zeitschrift für Krebsforschung, ISSN: 0171-5216, Vol: 65, Issue: 4, Page: 409-424
1963
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Article Description

Mitoses with genome segregation (Gläss) were detected in the livers of rats which had been given butter yellow; the frequencies of the genome segregations, their chromosomal combinations, and their behavior during the cancerogenesis were followed to and including the development of hepatomas. The higher the degree of ploidy, the more frequent were the cells with genomic segregation. With increasing concentrations of butter yellow the number of the euploid and aneuploid cells with genomic segregation rose. In hepatomas the number of cells with genome segregation fell. Diploid nuclei separated into single genomes, whereas in polyploid nuclei the separation occurred in groups with diploid chromosomal numbers. In aneuploid nuclei, in most instances, there was a separation into whole genomes plus an additional chromosomal group. With increasing dosage of butter yellow the number of unusual i. e. aneuploid genome segregations rose. Depending on the dosage of butter yellow new combinations of chromosomal numbers occurred that were not seen previously, and new aneuploid numbers thus developed (e. g., 18, 24, 48). Those aneuploid chromosome numbers, prefered in genome segregation can be demonstrated with equal frequency in metaphases of mitosis. Among 51 various aneuploid numbers in a total of 1903 mitoses, 14 were characterized by their marked frequency (a total of 84% of all aneuploidy). These 14 aneuploid numbers contained "functional groups" of 6 chromosomes each, which when added to a complete genome, guaranteed functionally competent aneuploid nuclei. © 1963 Springer-Verlag.

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