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Electron microscope investigations of reactive transformation of smooth muscle cells in the arterial wall under experimental conditions

Virchows Archiv Abteilung A Pathologische Anatomie, ISSN: 0945-6317, Vol: 359, Issue: 2, Page: 171-184
1973
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  • Citations
    11
    • Citation Indexes
      11

Article Description

Morphologic studies with the electron microscope were undertaken to point out the role of smooth muscle cells in experimental hypertension, hypercholesterinemia, and transplantation. Fine structural alterations are described and compared. It is shown that smooth muscle cells are able to transform under experimental conditions by loss of their characteristic morphological features. It is assumed that smooth muscle cells play an important role in the formation of pathologic intimal thickenings by migration into the subendothelial space and producing intercellular substances such as acid mucopolysaccharides, collagen and elastic. The smooth muscle cell is also considered to be capable of conversion into foam cell during lipid accumulation in the arterial wall following hypercholesterinemia. Smooth muscle cells are also important in the reparation of alterations in aortic grafts and hosts caused by ischemic and immunological reactions. © 1973 Springer-Verlag.

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