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The aldox-2 locus of Drosophila melanogaster also affects sulfite oxidase and molybdenum metabolism

Biochemical Genetics, ISSN: 0006-2928, Vol: 27, Issue: 1-2, Page: 99-118
1989
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Mutation at the aldox-2 locus in Drosophila melanogaster affects the specific activities of four molybdoenzymes differentially during development. Sulfite oxidase activity is normal during late larval and pupal stages but is reduced during early adult stages in aldox-2 organisms. There was complete concordance among the effects of aldox-2 on sulfite oxidase, aldehyde oxidase, xanthine dehydrogenase, and pyridoxal oxidase, when 38 stocks were analyzed which were derived from single recombination events between c and px, markers which flank aldox-2. Several different biochemical analyses indicate that the active molybdoenzymes present in the aldox-2 strain are normal with respect to size, shape, pH-activity profile, K, and molecular weight. Significant differences were found between the aldox-2 strain and the OR control strain in their responses to dietary NaMoO and NaWO. The mutant strain is much more resistant to the effects of dietary NaWO and much more responsive to the administration of NaMoO than the OR control strain when these effects are quantitated by measurements of molybdoenzyme specific activities. This evidence suggests that the aldox-2 gene product has a molybdenum binding site which can also bind tungsten and that this site is altered in the mutant strain. The hypothesis presented explains the observed effects of the aldox-2 mutation and relates them to the other mutations reported in this gene-enzyme system. © 1989 Plenum Publishing Corporation.

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