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Ionic determinants of bioelectrical spiking activity in the pancreatic B-cell

Pflügers Archiv European Journal of Physiology, ISSN: 0031-6768, Vol: 395, Issue: 3, Page: 201-203
1982
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Article Description

A rise in extracellular glucose concentration from 8.3 to 16.7 mM stimulates both Ca inflow and K exit in perfused rat pancreatic islets. These ionic changes are associated with an increase in bioelectrical spiking activity. From a quantitative analysis ofCa andRb outflow from prelabelled islets, it is proposed that each electrical spike coincides, approximately, with the entry of 0.8 fmol of Ca and exit of 3.6 fmol of K per mm of cell surface. © 1982 Springer-Verlag.

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