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Abnormal axonal discharges in R Neurones of Aplysia californica

Journal of Comparative Physiology □ A, ISSN: 0340-7594, Vol: 132, Issue: 2, Page: 127-139
1979
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Article Description

1. The neurone R of Aplysia is normally silent. The present paper describes an abnormal electrophysiological behaviour observed in 32 R neurones from Aplysia californica, which displayed long spiking discharges following synaptic or direct stimulations. 2. The discharge was studied with two intra-somatic microelectrodes and up to 3 extra-axonal electrodes located along the right pleurovisceral connective. 3. Both delay measurements and changes in the shape of the extra-axonal spikes showed that the discharge originated in an axonal area, located from 5 to 14 mm from the soma, where frequent blockade of conduction occurred. 4. Intracellular recordings were performed in this axonal area and in the soma. The axonal spike was followed by a depolarizing afterpotential (DAP) which could be summed resulting in a long axonal depolarization, with associated spiking, lasting up to 4 min. 5. The axonal long potential wave persisted when the soma was hyperpolarized or when the axon was sectioned near the soma. It was strongly attenuated by 10 M TTX but not affected by 10 mM cobalt. 6. A similar behaviour was observed in normal R neurones treated by low concentrations of the alkaloid veratridine (10 M): long discharges originating in the axon, blockade of the spike propagation, DAP's and long depolarizations. The DAP's of veratridinized R axons were reversibly blocked by 10 M TTX. 7. The analogies with the veratridine induced behaviour suggest that the abnormal long discharges result from the alteration of the sodium conductance in the proximal part of the axon of the cell. © 1979 Springer-Verlag.

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