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Time-dependent mixing and demixing processes in binary lipid monolayers studied by mixed and separate spreading using film pressure and film potential measurements

Colloid & Polymer Science, ISSN: 0303-402X, Vol: 269, Issue: 10, Page: 1026-1038
1991
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Article Description

Using both spreading techniques - mixed spreading and separate spreading- and, simultaneously, film pressure and film potential measurements, the mixing behavior of the following five binary systems was investigated and compared: 1) system 1,2-dilauroyl-phosphatidylethanolamine/cholesterol; 2) system 1,2-dimyristoyl-phosphatidylethanolamine/cholesterol; 3) system 1,2-dipalmitoyl-phosphatidylethanolamine/cholesterol; 4) system Na-eicosyl sulphate/hexadecanol; 5) system phosphatidic acid/1,2-dimyristoyl-phosphatidylethanolamine. Analyzing the time and concentration dependence of the π/a isotherms and Δv/a isotherms (π = film pressure, Δv potential, a=average area per molecule in mixed films in the monolayer s) of the binary monolayers it can be concluded that the components of the binary systems 1-4 are complete miscible in the monolayers. On the other hand the components of the system 5 are probably partially miscible only. © 1991 Steinkopff-Verlag.

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