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Functional sites in F-ATPases: Location and interactions

Journal of Bioenergetics and Biomembranes, ISSN: 0145-479X, Vol: 24, Issue: 5, Page: 469-477
1992
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Article Description

This review focuses on the location and interaction of three functional sites in F-ATPases. These are catalytic sites which are located in β subunits, noncatalytic nucleotide-binding sites which are located at interfaces of α and β subunits and modulate the hydrolytic activity of the enzyme, and a site that binds inhibitory amphipathic cations which is at an interface of α and β subunits. The latter site may participate in transmission of conformational signals between catalytic sites in F and the proton-conducting apparatus of F in the intact ATP synthases. © 1992 Plenum Publishing Corporation.

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