PlumX Metrics
Embed PlumX Metrics

Composition of hnRNA-associated proteins in rat liver is specifically altered after cycloheximide treatment

Molecular Biology Reports, ISSN: 0301-4851, Vol: 6, Issue: 1, Page: 57-61
1980
  • 2
    Citations
  • 0
    Usage
  • 0
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

Rats were treated with non-lethal doses of α-amanitin or cycloheximide. Nuclei were prepared and the particles carrying heterogeneous nuclear RNA (30-40 S-particles) isolated by density gradient centrifugation. In the case of α-amanitin the yield of particles was reduced to about 45%. Cycloheximide affected the composition of proteins associated with the nuclear RNA. In particular, the concentration of a 110 000 molecular weight protein as determined by sodium dodecylsulfate gel electrophoresis was reduced to 20-30% after 2 h and then increased to 150-180% of the control before it approached the normal level after 30 h. Possible mechanisms underlying these changes are discussed. © 1980 Dr. W. Junk B.V. Publishers, The Hague.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know