Glucose consumption and methionine uptake in low-grade gliomas after iodine-125 brachytherapy
European Journal of Nuclear Medicine, ISSN: 0340-6997, Vol: 23, Issue: 5, Page: 583-586
1996
- 87Citations
- 12Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations87
- Citation Indexes87
- 87
- CrossRef55
- Captures12
- Readers12
- 12
Article Description
We investigated whether 2-[F]-fluoro-2-deoxy-D-glucose (FDG) and carbon-11 methionine are suitable tracers to monitor the effects of therapy for low-grade gliomas. Ten patients with low-grade glioma without previous treatment were studied with FDG positron emission tomography. Additionally, L-[methyl-C]methionine uptake was measured in five subjects before and 1 year after computerized tomography (CT)-guided stereotactic and computer-assisted implantation of iodine-125 seeds. All scans were 3D-matched to CT, isodose volumes were determined, and changes in glucose metabolism and methionine uptake were evaluated in tumour and brain tissue as a function of radiation dose. After 1 year glucose metabolism was not significantly altered up to a radiation dose of 300 Gy, whereas methionine uptake showed a significant dose-dependent decrease. Higher rates of decline were found in tumours with high basal methionine incorporation activity before therapy. These data suggest that measurement of methionine uptake is more suitable than measurement of FDG uptake for monitoring therapeutic effects in low-grade gliomas.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0029962290&origin=inward; http://dx.doi.org/10.1007/bf00833397; http://www.ncbi.nlm.nih.gov/pubmed/8698067; http://link.springer.com/10.1007/BF00833397; http://www.springerlink.com/index/pdf/10.1007/BF00833397; https://dx.doi.org/10.1007/bf00833397; https://link.springer.com/article/10.1007/BF00833397; http://www.springerlink.com/index/10.1007/BF00833397
Springer Nature
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