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The morphology and enzyme - Histochemistry of acute renal failure

Virchows Archiv für Pathologische Anatomie und Physiologie und für Klinische Medizin, ISSN: 0945-6317, Vol: 336, Issue: 1, Page: 59-76
1962
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  • Citations
    6
    • Citation Indexes
      6
      • CrossRef
        6

Article Description

In the course of acute renal failure four histologic stages may be differentiated: 1. An early stage characterized by tubular dystrophy. This change, involving uniformly the whole kidney, may occur with preservation or with extensive loss of the enzymes or with tubular dilatation. 2. An intermediary stage, in which a tubular regeneration, arising in the corticomedullary zone, becomes prominent. At first, the regenerating epithelium is enzyme-negative; later during progressive differentiation it becomes enzymepositive. The epithelial dystrophy is focal. 3. A later stage, in which the mesenchymal reaction predominates (increase in interstitial cells, capillary proliferation, intravascular hematopoiesis). These changes are localized segmentally around the tubules. 4. A repeating form of acute renal failure, characterized by simultaneous necrosis and repair. © 1962 Springer-Verlag.

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