Effects of hemicholinium-3 and sodium ions on choline uptake system in excised superior cervical sympathetic ganglia of rats
Neurochemical Research, ISSN: 0364-3190, Vol: 14, Issue: 7, Page: 607-611
1989
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Article Description
Active choline uptake by rat superior cervical sympathetic ganglia (SCG), which contain abundant cholinergic nerve terminals, was studied with respect to sensitivity to inhibition by hemicholinium-3 (HC-3) and dependence on extracellular Na under standard conditions of assay. Choline was taken up by a single saturable process with apparent K=3.07×10 M and Vmax=286 pmoles/min/mg protein. Neither denervation followed by degeneration of cholinergic nerve terminals nor axotomy with successive neuronal degeneration significantly decreased in choline uptake by the ganglia in vitro. HC-3 dose-dependently inhibited ganglionic choline uptake more effectively at lower than at higher choline concentrations. HC-3 sensitive inhibition of ganglionic choline uptake was not seen in young rats one week after birth but appeared with maturity, attaining approximately 50% maximal inhibition in adult SCG. Extent of inhibition by HC-3 and Na dependence of ganglionic choline uptake was not altered by denervation or axotomy. © 1989 Plenum Publishing Corporation.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024376658&origin=inward; http://dx.doi.org/10.1007/bf00964868; http://www.ncbi.nlm.nih.gov/pubmed/2779724; http://link.springer.com/10.1007/BF00964868; http://www.springerlink.com/index/pdf/10.1007/BF00964868; http://www.springerlink.com/index/10.1007/BF00964868; https://dx.doi.org/10.1007/bf00964868; https://link.springer.com/article/10.1007/BF00964868
Springer Science and Business Media LLC
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