DNA sequences which influence the selection and efficient utilisation of transcriptional start sites of a eukaryotic gene by RNA polymerase II in vitro and in vivo
Bioscience Reports, ISSN: 0144-8463, Vol: 6, Issue: 11, Page: 937-944
1986
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
Experiments are described which probe the relationship between three sequence elements which make up the eukaryotic RNA polymerase II promoter. A cloned eukaryotic gene, from which the TATA-box and 400 base pairs of Y-flanking sequence has been deleted, is still transcriptionally active in vivo (following its transfection into cultured mammalian cells) and in vitro. Deletion has appropriately positioned a cluster of five TATA box-like sequences upstream from multiple potential cap sites. Which cap sites are actually used can be predicted from the DNA sequence of TATA box-like sequences and their spatial relationship with respect to possible transcriptional start sites, although there appears to be some difference in cap site utilisation in vitro and in vivo. Data suggest that deletion has also removed "upstream" sequences which affect promoter function. © 1986 Plenum Publishing Corporation.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0022990894&origin=inward; http://dx.doi.org/10.1007/bf01114969; http://www.ncbi.nlm.nih.gov/pubmed/3580519; https://portlandpress.com/bioscirep/article/6/11/937/55676/DNA-sequences-which-influence-the-selection-and; http://bioscirep.org/cgi/doi/10.1007/BF01114969; https://dx.doi.org/10.1007/bf01114969; https://portlandpress.com/bioscirep/article-abstract/6/11/937/55676/DNA-sequences-which-influence-the-selection-and?redirectedFrom=fulltext
Portland Press Ltd.
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