Decreased insulin binding and antilipolytic response in adipocytes from patients with Cushing's syndrome
Bioscience Reports, ISSN: 0144-8463, Vol: 7, Issue: 9, Page: 713-719
1987
- 7Citations
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations7
- Citation Indexes7
- CrossRef7
Article Description
Human adipocytes from patients with chronic endogenous hypercortisolism (Cushing's syndrome) showed a statistically significant decrease in insulin binding at low unlabelled-insulin concentrations but no change in receptor numbers (Cushing's 180,000±48,000 (3) receptors/cell and controls 189,000±30,000 (7)) together with a fourfold decrease in apparent receptor affinity (ED50: Cushing's 2.25×10 M and controls 0.57×10 M) and a decreased sensitivity to the antilipolytic effect of insulin. These events could represent the final situation of a chronic and endogenous regulation by high levels of cortisol of insulin receptors in human adipose tissue. © 1987 Plenum Publishing Corporation.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0023568469&origin=inward; http://dx.doi.org/10.1007/bf01116864; http://www.ncbi.nlm.nih.gov/pubmed/3322423; http://bioscirep.org/cgi/doi/10.1007/BF01116864; https://portlandpress.com/bioscirep/article/7/9/713/56455/Decreased-insulin-binding-and-antilipolytic; https://dx.doi.org/10.1007/bf01116864; https://portlandpress.com/bioscirep/article-abstract/7/9/713/56455/Decreased-insulin-binding-and-antilipolytic?redirectedFrom=fulltext
Portland Press Ltd.
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