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Decreased insulin binding and antilipolytic response in adipocytes from patients with Cushing's syndrome

Bioscience Reports, ISSN: 0144-8463, Vol: 7, Issue: 9, Page: 713-719
1987
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Article Description

Human adipocytes from patients with chronic endogenous hypercortisolism (Cushing's syndrome) showed a statistically significant decrease in insulin binding at low unlabelled-insulin concentrations but no change in receptor numbers (Cushing's 180,000±48,000 (3) receptors/cell and controls 189,000±30,000 (7)) together with a fourfold decrease in apparent receptor affinity (ED50: Cushing's 2.25×10 M and controls 0.57×10 M) and a decreased sensitivity to the antilipolytic effect of insulin. These events could represent the final situation of a chronic and endogenous regulation by high levels of cortisol of insulin receptors in human adipose tissue. © 1987 Plenum Publishing Corporation.

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