In vitro inhibition of rat liver DNA polymerases α and β by β-blockers
Bioscience Reports, ISSN: 1573-4935, Vol: 3, Issue: 3, Page: 299-308
1983
- 3Citations
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Metrics Details
- Citations3
- Citation Indexes3
- CrossRef3
Article Description
The activity of DNA polymerases α and β, isolated from regenerating rat liver, is inhibited, in a dose-dependent fashion, by the oncogenic β-blocker DL-I-(2-nitro-3-m ethyl-phenoxy) - 3-tert-butylamino-propan-2-ol (ZAM[ 1305) and by non-oncogenic β-blockers DL-l-(2-nitro-5-methyl- phenoxy-3-tert-butylamino-propan-2-ol (ZAMI 1327) and DL-propranolol. The inhibition is due to a reversible interaction of the g-blockers with the two DNA polymerases. The interaction does not involve the template-DNA-binding site or the deoxynucleotide-binding site of the enzyme molecule. The degree of inhibition appears to be related to the hydrophobicity of the aromatic moiety and to the length and/or hydrophilicity of the aliphatic chain of the β-blocker molecule. These results may explain the transient in vivo inhibition of hepatic DNA synthesis observed in female rats treated with ZAMI 1305 or ZAMI 1327. © 1983 The Biochemical Society.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0020621033&origin=inward; http://dx.doi.org/10.1007/bf01122463; https://portlandpress.com/bioscirep/article/3/3/299/55211/In-vitro-inhibition-of-rat-liver-DNA-polymerases; https://portlandpress.com/bioscirep/article-pdf/3/3/299/470767/bsr0030299.pdf; http://bioscirep.org/cgi/doi/10.1007/BF01122463; https://dx.doi.org/10.1007/bf01122463; https://portlandpress.com/bioscirep/article-abstract/3/3/299/55211/In-vitro-inhibition-of-rat-liver-DNA-polymerases?redirectedFrom=fulltext
Portland Press Ltd.
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