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Localization of melanotropin-like peptides in the central nervous system of two insect species, the migratory locust, Locusta migratoria, and the fleshfly, Sarcophaga bullata

Cell and Tissue Research, ISSN: 0302-766X, Vol: 248, Issue: 1, Page: 25-31
1987
  • 27
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  • Citations
    27
    • Citation Indexes
      27
  • Captures
    7

Article Description

By use of well characterized antisera in the peroxidase-antiperoxidase method, we were able to demonstrate αMSH and βMSH immunoreactive cells and nerve fibres within the nervous system of adults and larvae of Locusta migratoria and 3-, 5- and 8-day-old adult Sarcophaga bullata. In neither of these insect species, any immunoreaction was obtained with a γMSH-antiserum. Double immuno-histochemical stainings revealed that αMSH-like and βMSH-like substances are located in different cells. These cells show no immunoreactivity to a number of antisera against other POMC-derivatives (anti-βlipotropin, anti-βendorphin, anti-ACTH); thus they appear to contain αMSH- or βMSH-like material in a specific way. The function of the immunologically detected peptides remains to be demonstrated. The distribution of the immunoreactive material suggests that, like in amphibians and other lower vertebrates, the synthesis or release of melanotropins might be under the influence of external stimuli. The present observations support the recently developed concept that even some of the smallest neuropeptides, the melanotropins, have been highly conserved during a long period of evolution. © 1987 Springer-Verlag.

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