Striatal dopamine in motor activation and reward-mediated learning: steps towards a unifying model
Journal of Neural Transmission, ISSN: 0300-9564, Vol: 80, Issue: 1, Page: 9-31
1990
- 117Citations
- 70Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations117
- Citation Indexes117
- 117
- CrossRef94
- Captures70
- Readers70
- 70
Article Description
On the basis of behavioural evidence, dopamine is found to be involved in two higher-level functions of the brain: reward-mediated learning and motor activation. In these functions dopamine appears to mediate synaptic enhancement in the corticostriatal pathway. However, in electrophysiological studies, dopamine is often reported to inhibit corticostriatal transmission. These two effects of dopamine seem incompatible. The existence of separate populations of dopamine receptors, differentially modulating cholinergic and glutamatergic synapses, suggests a possible resolution to this paradox. The synaptic enhancement which occurs in reward-mediated learning may also be involved in dopamine-mediated motor activation. The logical form of reward-mediated learning imposes constraints on which mechanisms can be considered possible. Dopamine D1 receptors may mediate enhancement of corticostriatal synapses. On the other hand, dopamine D2 receptors on cholinergic terminals may mediate indirect, inhibitory effects of dopamine on striatal neurons. © 1990 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0025020164&origin=inward; http://dx.doi.org/10.1007/bf01245020; http://www.ncbi.nlm.nih.gov/pubmed/2407269; http://link.springer.com/10.1007/BF01245020; http://www.springerlink.com/index/pdf/10.1007/BF01245020; https://dx.doi.org/10.1007/bf01245020; https://link.springer.com/article/10.1007/BF01245020; http://www.springerlink.com/index/10.1007/BF01245020
Springer Science and Business Media LLC
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