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Caffeine withdrawal affects central adenosine receptors but not benzodiazepine receptors

Journal of Neural Transmission, ISSN: 0300-9564, Vol: 78, Issue: 1, Page: 9-15
1989
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Article Description

The effects of chronic caffeine administration on both adenosine and benzodiazepine receptors were studied in mouse brain membranes. Animals were fed on a diet enriched with caffeine (600 mg/kg diet) for 15 days and sacrificed 2, 4, 8 and 15 days after withdrawal. Compared with controls fed on a regular diet, animals receiving a caffeine-enriched diet showed an increase in the number of brain adenosine receptors labeled with [H]-DPX in both the cerebellum and forebrain regions. This up-regulation was still significant 15 days after withdrawal in the cerebellum but not in the forebrain, where the number of adenosine receptors returned to control levels within 8 days following withdrawal. Benzodiazepine receptors labeled by [H]-B-CCE were not influenced by chronic caffeine diet or withdrawal. © 1989 Springer-Verlag.

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