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Species dependent effects of dihydroergosine on [H]TBOB binding to membranes from the human, rat, bovine and mouse brain

Journal of Neural Transmission, ISSN: 0300-9564, Vol: 90, Issue: 3, Page: 225-230
1992
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Dihydroergosine enhanced [H]TBOB binding to the crude synaptosomal membranes prepared from the whole rat brain and human frontal cortex. Higher concentrations of the same drug inhibited [H]TBOB binding in the preparations obtained from the whole mouse brain and bovine frontal cortex. Bicuculline-induced enhancement and GABA- or diazepam-induced inhibition of [H]TBOB binding were similar in the four species examined. The results indicate that dihydroergosine modulates species-dependently GABA/ benzodiazepine receptors. © 1992 Springer-Verlag.

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