High sensitivity of DNA replication to 5-aminouracil in the middle of the S period
Protoplasma, ISSN: 0033-183X, Vol: 121, Issue: 1-2, Page: 138-145
1984
- 9Citations
- 1Captures
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Article Description
Cell distribution in different compartments of the cell cycle (G, early, middle and late S, G and mitosis) has been studied during treatment with 0.5 mM 5-aminouracil and recovery in Allium cepa L. root meristems by cytophotometric and autoradiographic methods. At optimum conditions for obtaining mitotic synchronization, 5-aminouracil gives rise to cell accumulation in the S period, preferentially in its middle zone where the relative DNA content is 2.8 ± 0.1 C. After a 14-hour treatment 33% of the proliferative population is accumulated in this particular region. During recovery, a drastic reduction of the S phase and a clear increase of the mitotic frequency are the most important events observed. Apparently, the removal of the drug frees the blockage and the accumulated cells complete their interphase making up the mitotic wave. © 1984 Springer-Verlag.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0006022006&origin=inward; http://dx.doi.org/10.1007/bf01279761; http://link.springer.com/10.1007/BF01279761; http://www.springerlink.com/index/pdf/10.1007/BF01279761; http://link.springer.com/content/pdf/10.1007/BF01279761; http://link.springer.com/content/pdf/10.1007/BF01279761.pdf; http://link.springer.com/article/10.1007/BF01279761/fulltext.html; https://dx.doi.org/10.1007/bf01279761; https://link.springer.com/article/10.1007/BF01279761; http://www.springerlink.com/index/10.1007/BF01279761
Springer Science and Business Media LLC
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